Sign on

SAO/NASA ADS General Science Abstract Service

· Find Similar Abstracts (with default settings below)
· Electronic Refereed Journal Article (HTML)
· References in the article
· Citations to the Article (20) (Citation History)
· Refereed Citations to the Article
· Reads History
·
· Translate This Page
Title:
Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans
Authors:
Greer, Eric L.; Maures, Travis J.; Ucar, Duygu; Hauswirth, Anna G.; Mancini, Elena; Lim, Jana P.; Benayoun, Bérénice A.; Shi, Yang; Brunet, Anne
Affiliation:
AA(Department of Genetics, Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA), AB(Department of Genetics, Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA), AC(Department of Genetics, Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA), AD(Department of Genetics, Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA), AE(Department of Genetics, Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA), AF(Department of Genetics, Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA), AG(Department of Genetics, Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA), AH(Cell Biology Department, Harvard Medical School and Division of Newborn Medicine, Children's Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA), AI(Department of Genetics, Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA)
Publication:
Nature, Volume 479, Issue 7373, pp. 365-371 (2011). (Nature Homepage)
Publication Date:
11/2011
Origin:
NATURE
Abstract Copyright:
(c) 2011: Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
DOI:
10.1038/nature10572
Bibliographic Code:
2011Natur.479..365G

Abstract

Chromatin modifiers regulate lifespan in several organisms, raising the question of whether changes in chromatin states in the parental generation could be incompletely reprogrammed in the next generation and thereby affect the lifespan of descendants. The histone H3 lysine 4 trimethylation (H3K4me3) complex, composed of ASH-2, WDR-5 and the histone methyltransferase SET-2, regulates Caenorhabditis elegans lifespan. Here we show that deficiencies in the H3K4me3 chromatin modifiers ASH-2, WDR-5 or SET-2 in the parental generation extend the lifespan of descendants up until the third generation. The transgenerational inheritance of lifespan extension by members of the ASH-2 complex is dependent on the H3K4me3 demethylase RBR-2, and requires the presence of a functioning germline in the descendants. Transgenerational inheritance of lifespan is specific for the H3K4me3 methylation complex and is associated with epigenetic changes in gene expression. Thus, manipulation of specific chromatin modifiers only in parents can induce an epigenetic memory of longevity in descendants.
Bibtex entry for this abstract   Preferred format for this abstract (see Preferences)

Find Similar Abstracts:

Use: Authors
Title
Abstract Text
Return: Query Results Return    items starting with number
Query Form
Database: Astronomy
Physics
arXiv e-prints