Sign on

SAO/NASA ADS General Science Abstract Service

· Find Similar Abstracts (with default settings below)
· Electronic Refereed Journal Article (HTML)
· Full Refereed Journal Article (PDF/Postscript)
· Also-Read Articles (Reads History)
·
· Translate This Page
Title:
Sequencing and Analyses of All Known Human Rhinovirus Genomes Reveal Structure and Evolution
Authors:
Palmenberg, Ann C.; Spiro, David; Kuzmickas, Ryan; Wang, Shiliang; Djikeng, Appolinaire; Rathe, Jennifer A.; Fraser-Liggett, Claire M.; Liggett, Stephen B.
Affiliation:
AA(Institute for Molecular Virology, University of Wisconsin, Madison, WI 53706, USA.), AB(J. Craig Venter Institute, Rockville, MD 20850, USA.), AC(J. Craig Venter Institute, Rockville, MD 20850, USA.), AD(J. Craig Venter Institute, Rockville, MD 20850, USA.), AE(J. Craig Venter Institute, Rockville, MD 20850, USA.), AF(Cardiopulmonary Genomics Program, University of Maryland School of Medicine, Baltimore, MD 21201, USA.), AG(Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA.), AH(Cardiopulmonary Genomics Program, University of Maryland School of Medicine, Baltimore, MD 21201, USA.)
Publication:
Science, Volume 324, Issue 5923, pp. 55- (2009).
Publication Date:
04/2009
Origin:
SCIENCE
Abstract Copyright:
(c) 2009: Science
DOI:
10.1126/science.1165557
Bibliographic Code:
2009Sci...324...55P

Abstract

Infection by human rhinovirus (HRV) is a major cause of upper and lower respiratory tract disease worldwide and displays considerable phenotypic variation. We examined diversity by completing the genome sequences for all known serotypes (n = 99). Superimposition of capsid crystal structure and optimal-energy RNA configurations established alignments and phylogeny. These revealed conserved motifs; clade-specific diversity, including a potential newly identified species (HRV-D); mutations in field isolates; and recombination. In analogy with poliovirus, a hypervariable 5′ untranslated region tract may affect virulence. A configuration consistent with nonscanning internal ribosome entry was found in all HRVs and may account for rapid translation. The data density from complete sequences of the reference HRVs provided high resolution for this degree of modeling and serves as a platform for full genome-based epidemiologic studies and antiviral or vaccine development.
Bibtex entry for this abstract   Preferred format for this abstract (see Preferences)
   

Find Similar Abstracts:

Use: Authors
Title
Abstract Text
Return: Query Results Return    items starting with number
Query Form
Database: Astronomy
Physics
arXiv e-prints