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Title:
Replication and protection of telomeres
Authors:
Verdun, Ramiro E.; Karlseder, Jan
Affiliation:
AA(The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037-1099, USA.), AB(The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037-1099, USA.)
Publication:
Nature, Volume 447, Issue 7147, pp. 924-931 (2007). (Nature Homepage)
Publication Date:
06/2007
Origin:
NATURE
Abstract Copyright:
(c) 2007: Nature
DOI:
10.1038/nature05976
Bibliographic Code:
2007Natur.447..924V

Abstract

During the evolution of linear genomes, it became essential to protect the natural chromosome ends to prevent triggering of the DNA-damage repair machinery and enzymatic attack. Telomeres - tightly regulated complexes consisting of repetitive G-rich DNA and specialized proteins - accomplish this task. Telomeres not only conceal linear chromosome ends from detection and inappropriate repair but also provide a buffer to counteract replication-associated shortening. Lessons from many model organisms have taught us about the complications of maintaining these specialized structures. Here, we discuss how telomeres interact and cooperate with the DNA replication and DNA-damage repair machineries.
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Database: Astronomy
Physics
arXiv e-prints