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Title:
Genome-wide atlas of gene expression in the adult mouse brain
Authors:
Lein, Ed S.; Hawrylycz, Michael J.; Ao, Nancy; Ayres, Mikael; Bensinger, Amy; Bernard, Amy; Boe, Andrew F.; Boguski, Mark S.; Brockway, Kevin S.; Byrnes, Emi J.; Chen, Lin; Chen, Li; Chen, Tsuey-Ming; Chi Chin, Mei; Chong, Jimmy; Crook, Brian E.; Czaplinska, Aneta; Dang, Chinh N.; Datta, Suvro; Dee, Nick R.; Desaki, Aimee L.; Desta, Tsega; Diep, Ellen; Dolbeare, Tim A.; Donelan, Matthew J.; Dong, Hong-Wei; Dougherty, Jennifer G.; Duncan, Ben J.; Ebbert, Amanda J.; Eichele, Gregor; Estin, Lili K.; Faber, Casey; Facer, Benjamin A.; Fields, Rick; Fischer, Shanna R.; Fliss, Tim P.; Frensley, Cliff; Gates, Sabrina N.; Glattfelder, Katie J.; Halverson, Kevin R.; Hart, Matthew R.; Hohmann, John G.; Howell, Maureen P.; Jeung, Darren P.; Johnson, Rebecca A.; Karr, Patrick T.; Kawal, Reena; Kidney, Jolene M.; Knapik, Rachel H.; Kuan, Chihchau L.; Lake, James H.; Laramee, Annabel R.; Larsen, Kirk D.; Lau, Christopher; Lemon, Tracy A.; Liang, Agnes J.; Liu, Ying; Luong, Lon T.; Michaels, Jesse; Morgan, Judith J.; Morgan, Rebecca J.; Mortrud, Marty T.; Mosqueda, Nerick F.; Ng, Lydia L.; Ng, Randy; Orta, Geralyn J.; Overly, Caroline C.; Pak, Tu H.; Parry, Sheana E.; Pathak, Sayan D.; Pearson, Owen C.; Puchalski, Ralph B.; Riley, Zackery L.; Rockett, Hannah R.; Rowland, Stephen A.; Royall, Joshua J.; Ruiz, Marcos J.; Sarno, Nadia R.; Schaffnit, Katherine; Shapovalova, Nadiya V.; Sivisay, Taz; Slaughterbeck, Clifford R.; Smith, Simon C.; Smith, Kimberly A.; Smith, Bryan I.; Sodt, Andy J.; Stewart, Nick N.; Stumpf, Kenda-Ruth; Sunkin, Susan M.; Sutram, Madhavi; Tam, Angelene; Teemer, Carey D.; Thaller, Christina; Thompson, Carol L.; Varnam, Lee R.; Visel, Axel; Whitlock, Ray M.; Wohnoutka, Paul E.; Wolkey, Crissa K.; Wong, Victoria Y.; Wood, Matthew; Yaylaoglu, Murat B.; Young, Rob C.; Youngstrom, Brian L.; Feng Yuan, Xu; Zhang, Bin; Zwingman, Theresa A.; Jones, Allan R.
Affiliation:
AA(Allen Institute for Brain Science, Seattle, Washington 98103, USA), AB(Allen Institute for Brain Science, Seattle, Washington 98103, USA), AC(Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA), AD(Allen Institute for Brain Science, Seattle, Washington 98103, USA), AE(Allen Institute for Brain Science, Seattle, Washington 98103, USA), AF(Allen Institute for Brain Science, Seattle, Washington 98103, USA), AG(Allen Institute for Brain Science, Seattle, Washington 98103, USA), AH(Allen Institute for Brain Science, Seattle, Washington 98103, USA), AI(Allen Institute for Brain Science, Seattle, Washington 98103, USA), AJ(Allen Institute for Brain Science, Seattle, Washington 98103, USA), AK(Allen Institute for Brain Science, Seattle, Washington 98103, USA), AL(Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA), AM(Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA), AN(Allen Institute for Brain Science, Seattle, Washington 98103, USA), AO(Allen Institute for Brain Science, Seattle, Washington 98103, USA), AP(Allen Institute for Brain Science, Seattle, Washington 98103, USA), AQ(Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA), AR(Allen Institute for Brain Science, Seattle, Washington 98103, USA), AS(Allen Institute for Brain Science, Seattle, Washington 98103, USA), AT(Allen Institute for Brain Science, Seattle, Washington 98103, USA), AU(Allen Institute for Brain Science, Seattle, Washington 98103, USA), AV(Allen Institute for Brain Science, Seattle, Washington 98103, USA), AW(Allen Institute for Brain Science, Seattle, Washington 98103, USA), AX(Allen Institute for Brain Science, Seattle, Washington 98103, USA), AY(Allen Institute for Brain Science, Seattle, Washington 98103, USA), AZ(Allen Institute for Brain Science, Seattle, Washington 98103, USA), BA(Allen Institute for Brain Science, Seattle, Washington 98103, USA), BB(Allen Institute for Brain Science, Seattle, Washington 98103, USA), BC(Allen Institute for Brain Science, Seattle, Washington 98103, USA), BD(Department of Genes and Behavior, Max Planck Institute of Biophysical Chemistry, 37077 Goettingen, Germany), BE(Allen Institute for Brain Science, Seattle, Washington 98103, USA), BF(Allen Institute for Brain Science, Seattle, Washington 98103, USA), BG(Allen Institute for Brain Science, Seattle, Washington 98103, USA), BH(Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA), BI(Allen Institute for Brain Science, Seattle, Washington 98103, USA), BJ(Allen Institute for Brain Science, Seattle, Washington 98103, USA), BK(Allen Institute for Brain Science, Seattle, Washington 98103, USA), BL(Allen Institute for Brain Science, Seattle, Washington 98103, USA), BM(Allen Institute for Brain Science, Seattle, Washington 98103, USA), BN(Allen Institute for Brain Science, Seattle, Washington 98103, USA), BO(Allen Institute for Brain Science, Seattle, Washington 98103, USA), BP(Allen Institute for Brain Science, Seattle, Washington 98103, USA), BQ(Allen Institute for Brain Science, Seattle, Washington 98103, USA), BR(Allen Institute for Brain Science, Seattle, Washington 98103, USA), BS(Allen Institute for Brain Science, Seattle, Washington 98103, USA), BT(Allen Institute for Brain Science, Seattle, Washington 98103, USA), BU(Allen Institute for Brain Science, Seattle, Washington 98103, USA), BV(Allen Institute for Brain Science, Seattle, Washington 98103, USA), BW(Allen Institute for Brain Science, Seattle, Washington 98103, USA), BX(Allen Institute for Brain Science, Seattle, Washington 98103, USA), BY(Allen Institute for Brain Science, Seattle, Washington 98103, USA), BZ(Allen Institute for Brain Science, Seattle, Washington 98103, USA), CA(Allen Institute for Brain Science, Seattle, Washington 98103, USA), CB(Allen Institute for Brain Science, Seattle, Washington 98103, USA), CC(Allen Institute for Brain Science, Seattle, Washington 98103, USA), CD(Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA), CE(Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA), CF(Allen Institute for Brain Science, Seattle, Washington 98103, USA), CG(Allen Institute for Brain Science, Seattle, Washington 98103, USA), CH(Allen Institute for Brain Science, Seattle, Washington 98103, USA), CI(Allen Institute for Brain Science, Seattle, Washington 98103, USA), CJ(Allen Institute for Brain Science, Seattle, Washington 98103, USA), CK(Allen Institute for Brain Science, Seattle, Washington 98103, USA), CL(Allen Institute for Brain Science, Seattle, Washington 98103, USA), CM(Allen Institute for Brain Science, Seattle, Washington 98103, USA), CN(Allen Institute for Brain Science, Seattle, Washington 98103, USA), CO(Allen Institute for Brain Science, Seattle, Washington 98103, USA), CP(Allen Institute for Brain Science, Seattle, Washington 98103, USA), CQ(Allen Institute for Brain Science, Seattle, Washington 98103, USA), CR(Allen Institute for Brain Science, Seattle, Washington 98103, USA), CS(Allen Institute for Brain Science, Seattle, Washington 98103, USA), CT(Allen Institute for Brain Science, Seattle, Washington 98103, USA), CU(Allen Institute for Brain Science, Seattle, Washington 98103, USA), CV(Allen Institute for Brain Science, Seattle, Washington 98103, USA), CW(Allen Institute for Brain Science, Seattle, Washington 98103, USA), CX(Allen Institute for Brain Science, Seattle, Washington 98103, USA), CY(Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA), CZ(Allen Institute for Brain Science, Seattle, Washington 98103, USA), DA(Allen Institute for Brain Science, Seattle, Washington 98103, USA), DB(Allen Institute for Brain Science, Seattle, Washington 98103, USA), DC(Allen Institute for Brain Science, Seattle, Washington 98103, USA), DD(Allen Institute for Brain Science, Seattle, Washington 98103, USA), DE(Allen Institute for Brain Science, Seattle, Washington 98103, USA), DF(Allen Institute for Brain Science, Seattle, Washington 98103, USA), DG(Allen Institute for Brain Science, Seattle, Washington 98103, USA), DH(Allen Institute for Brain Science, Seattle, Washington 98103, USA), DI(Allen Institute for Brain Science, Seattle, Washington 98103, USA), DJ(Allen Institute for Brain Science, Seattle, Washington 98103, USA), DK(Allen Institute for Brain Science, Seattle, Washington 98103, USA), DL(Allen Institute for Brain Science, Seattle, Washington 98103, USA), DM(Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA), DN(Allen Institute for Brain Science, Seattle, Washington 98103, USA), DO(Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA), DP(Allen Institute for Brain Science, Seattle, Washington 98103, USA), DQ(Allen Institute for Brain Science, Seattle, Washington 98103, USA), DR(Department of Genes and Behavior, Max Planck Institute of Biophysical Chemistry, 37077 Goettingen, Germany), DS(Allen Institute for Brain Science, Seattle, Washington 98103, USA), DT(Allen Institute for Brain Science, Seattle, Washington 98103, USA), DU(Allen Institute for Brain Science, Seattle, Washington 98103, USA), DV(Allen Institute for Brain Science, Seattle, Washington 98103, USA), DW(Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA), DX(Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA), DY(Allen Institute for Brain Science, Seattle, Washington 98103, USA), DZ(Allen Institute for Brain Science, Seattle, Washington 98103, USA), EA(Allen Institute for Brain Science, Seattle, Washington 98103, USA), EB(Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA), EC(Allen Institute for Brain Science, Seattle, Washington 98103, USA), EE(Allen Institute for Brain Science, Seattle, Washington 98103, USA)
Publication:
Nature, Volume 445, Issue 7124, pp. 168-176 (2007). (Nature Homepage)
Publication Date:
01/2007
Origin:
NATURE
Abstract Copyright:
(c) 2007: Nature
DOI:
10.1038/nature05453
Bibliographic Code:
2007Natur.445..168L

Abstract

Molecular approaches to understanding the functional circuitry of the nervous system promise new insights into the relationship between genes, brain and behaviour. The cellular diversity of the brain necessitates a cellular resolution approach towards understanding the functional genomics of the nervous system. We describe here an anatomically comprehensive digital atlas containing the expression patterns of ~20,000 genes in the adult mouse brain. Data were generated using automated high-throughput procedures for in situ hybridization and data acquisition, and are publicly accessible online. Newly developed image-based informatics tools allow global genome-scale structural analysis and cross-correlation, as well as identification of regionally enriched genes. Unbiased fine-resolution analysis has identified highly specific cellular markers as well as extensive evidence of cellular heterogeneity not evident in classical neuroanatomical atlases. This highly standardized atlas provides an open, primary data resource for a wide variety of further studies concerning brain organization and function.
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