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Title:
Mechanisms of gene silencing by double-stranded RNA
Authors:
Meister, Gunter; Tuschl, Thomas
Affiliation:
AA(Laboratory of RNA Molecular Biology, The Rockefeller University, 1230 York Avenue, Box 186, New York, New York 10021, USA (e-mail: )), AB(Laboratory of RNA Molecular Biology, The Rockefeller University, 1230 York Avenue, Box 186, New York, New York 10021, USA (e-mail: ))
Publication:
Nature, Volume 431, Issue 7006, pp. 343-349 (2004). (Nature Homepage)
Publication Date:
09/2004
Origin:
NATURE
Abstract Copyright:
(c) 2004: Nature
DOI:
10.1038/nature02873
Bibliographic Code:
2004Natur.431..343M

Abstract

Double-stranded RNA (dsRNA) is an important regulator of gene expression in many eukaryotes. It triggers different types of gene silencing that are collectively referred to as RNA silencing or RNA interference. A key step in known silencing pathways is the processing of dsRNAs into short RNA duplexes of characteristic size and structure. These short dsRNAs guide RNA silencing by specific and distinct mechanisms. Many components of the RNA silencing machinery still need to be identified and characterized, but a more complete understanding of the process is imminent.
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Database: Astronomy
Physics
arXiv e-prints