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Title:
Strand-Specific Postreplicative Processing of Mammalian Telomeres
Authors:
Bailey, S. M.; Cornforth, M. N.; Kurimasa, A.; Chen, D. J.; Goodwin, E. H.
Affiliation:
AA(Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87544, USA.), AB(Department of Radiation Oncology, University of Texas Medical Branch, Galveston, TX 77550, USA.), AC(Cell and Molecular Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.), AD(Cell and Molecular Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.), AE(Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87544, USA.)
Publication:
Science, Volume 293, Issue 5539, pp. 2462-2465 (2001).
Publication Date:
09/2001
Category:
CELL BIOL
Origin:
SCIENCE
Abstract Copyright:
(c) 2001: Science
Bibliographic Code:
2001Sci...293.2462B

Abstract

Telomeres are specialized nucleoprotein structures that stabilize the ends of linear eukaryotic chromosomes. In mammalian cells, abrogation of telomeric repeat binding factor TRF2 or DNA-dependent protein kinase (DNA-PK) activity causes end-to-end chromosomal fusion, thus establishing an essential role for these proteins in telomere function. Here we show that TRF2-mediated end-capping occurs after telomere replication. The postreplicative requirement for TRF2 and DNA-PKcs, the catalytic subunit of DNA-PK, is confined to only half of the telomeres, namely, those that were produced by leading-strand DNA synthesis. These results demonstrate a crucial difference in postreplicative processing of telomeres that is linked to their mode of replication.
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