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Title:
Signaling and Circuitry of Multiple MAPK Pathways Revealed by a Matrix of Global Gene Expression Profiles
Authors:
Roberts, Christopher J.; Nelson, Bryce; Marton, Matthew J.; Stoughton, Roland; Meyer, Michael R.; Bennett, Holly A.; He, Yudong D.; Dai, Hongyue; Walker, Wynn L.; Hughes, Timothy R.; Tyers, Mike; Boone, Charles; Friend, Stephen H.
Affiliation:
AA(Rosetta Inpharmatics, 12040 115th Avenue Northeast, Kirkland, WA 98034, USA.), AB(Biology Department, Queen's University, Kingston, Ontario K7L 3N6, Canada.), AC(Rosetta Inpharmatics, 12040 115th Avenue Northeast, Kirkland, WA 98034, USA.), AD(Rosetta Inpharmatics, 12040 115th Avenue Northeast, Kirkland, WA 98034, USA.), AE(Rosetta Inpharmatics, 12040 115th Avenue Northeast, Kirkland, WA 98034, USA.), AF(Rosetta Inpharmatics, 12040 115th Avenue Northeast, Kirkland, WA 98034, USA.), AG(Rosetta Inpharmatics, 12040 115th Avenue Northeast, Kirkland, WA 98034, USA.), AH(Rosetta Inpharmatics, 12040 115th Avenue Northeast, Kirkland, WA 98034, USA.), AI(Rosetta Inpharmatics, 12040 115th Avenue Northeast, Kirkland, WA 98034, USA.), AJ(Rosetta Inpharmatics, 12040 115th Avenue Northeast, Kirkland, WA 98034, USA.), AK(Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Room 1080, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada.), AL(Biology Department, Queen's University, Kingston, Ontario K7L 3N6, Canada.), AM(Rosetta Inpharmatics, 12040 115th Avenue Northeast, Kirkland, WA 98034, USA.)
Publication:
Science, Volume 287, Issue 5454, pp. 873-880 (2000).
Publication Date:
02/2000
Category:
CELL BIOL
Origin:
SCIENCE
Abstract Copyright:
(c) 2000: Science
Bibliographic Code:
2000Sci...287..873R

Abstract

Genome-wide transcript profiling was used to monitor signal transduction during yeast pheromone response. Genetic manipulations allowed analysis of changes in gene expression underlying pheromone signaling, cell cycle control, and polarized morphogenesis. A two-dimensional hierarchical clustered matrix, covering 383 of the most highly regulated genes, was constructed from 46 diverse experimental conditions. Diagnostic subsets of coexpressed genes reflected signaling activity, cross talk, and overlap of multiple mitogen-activated protein kinase (MAPK) pathways. Analysis of the profiles specified by two different MAPKs-Fus3p and Kss1p-revealed functional overlap of the filamentous growth and mating responses. Global transcript analysis reflects biological responses associated with the activation and perturbation of signal transduction pathways.
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