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Title:
Defined Dimensional Changes in Enzyme Cofactors: Fluorescent "Stretched-Out" Analogs of Adenine Nucleotides
Authors:
Scopes, David I. C.; Barrio, Jorge R.; Leonard, Nelson J.
Publication:
Science, Volume 195, Issue 4275, pp. 296-298 (Sci Homepage)
Publication Date:
01/1977
Origin:
JSTOR
DOI:
10.1126/science.188137
Bibliographic Code:
1977Sci...195..296S

Abstract

A concept is presented for testing the dimensional restrictions of enzyme-active sites by stretching the substrate or cofactor by known magnitude. These restrictions of enzyme-active sites specific for purine cofactors were tested by the synthesis and evaluation of lin-benzoadenosine 5'-triphosphate, 5'-diphosphate, and 3', 5'-monophosphate with respect to enzyme binding and activity. These "stretchedout" (by 2.4 angstroms) versions of the adenine ribonucleotides bind strongly, slow the enzymatic rates, and have useful fluorescence properties.
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Database: Astronomy
Physics
arXiv e-prints