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Title:
Restriction of the Mobility of Lymphocyte Immunoglobulin Receptors by Concanavalin A
Authors:
Yahara, Ichiro; Edelman, Gerald M.
Publication:
Proceedings of the National Academy of Sciences of the United States of America, Volume 69, Issue 3, pp. 608-612
Publication Date:
03/1972
Origin:
JSTOR
DOI:
10.1073/pnas.69.3.608
Bibliographic Code:
1972PNAS...69..608Y

Abstract

The induction by anti-immunoglobulin of patch and cap formation on mouse lymphocytes was inhibited by the addition of concanavalin A. This effect was reversed by alpha -methyl-D-mannoside, a competitive inhibitor of the binding of concanavalin A. Concanavalin A prevented both patch and cap formation, in contrast to the metabolic inhibitor NaN3, which prevented only cap formation. This suggests that binding of concanavalin A induces changes on or in the lymphocyte membrane that inhibit free diffusion of immunoglobulin receptors.
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